I don’t know what they were expecting, keeping it around all those streams and lakes.

Don’t feed the trolls, especially the ones that are bad at it. But yeah, this app doesn’t let you select and uninstall multiple things at the same time nor does it have all the functionality of Synaptic (which is amaze, notably for the search tool). I’d settle on a CLI tool for this too, I just want a one stop shop because I get so triggered having to juggle different managers. It’s just fucking annoying really. Like, I found the cli tool Topgrade and it is just the best thing ever for keeping things up to date from all package managers, I want that with extended functionality as even this tool doesn’t manage every manager that Topgrade does. Something modular, otherwise I waste time fucking around with everything. That’s really the core issue, it’s a pain in the ass not being centralised. If I had more time and unlimited finances I’d fork this and try to extend it myself.

Hmm… very mammalian.

ur a dick with a toupe

Maybe consider why you are being downvoted. Have a good one.

Mate, you are not being clear at all. I’ve clarified this multiple times. If you’re unwilling to acknowledge that out-of-the-box package managers do not generally include non-native package formats, this conversation can’t progress.

I did not make this. This does include Snaps and Flatpaks and Debs and a lot of other formats. Your general package managers do not.

It does not include appimages or various other formats that are included in this app. This is an all in one solution.

This is why I do this.

I want to see it all in a single database and manage it all in one place in a GUI with multi select.

God, this is a great start to whaat I want. I want this to have a baby with Synaptic. This is great for cleaning up though.

They look like nightmare pets but oh boy do I want to play with one.

lol no, I have had problems in the UK and Europe. The old world is extremely hierarchical and the older generations have some weird lingering quasi-religous gender issues.

Geddon then. ;)

Oggy oggy oggy.

The Lizard is a great spot.

Here is a summary with a link to the PDF: https://bigthink.com/health/carl-sagan-on-smoking-marijuana/

It’s a cell biology joke about the ubiquitin system.

https://www.nature.com/articles/458421a

Others can correct me if I’m wrong (pls do this isnt my area), but in normal cell biology, you usually tag the misfolded or regulated proteins for destruction. Here, the meme brags that they’ve been tagging properly folded proteins instead.

From the link:

The destruction of proteins is as important as their synthesis for the maintenance of protein homeostasis in cells. In eukaryotes, the ubiquitin–proteasome system is responsible for most of this protein degradation: the small protein ubiquitin acts as a death warrant, tagging and targeting other proteins to the large proteolytic chamber of the proteasome.

The discovery in the 1970s that certain proteins are ubiquitylated before degradation was awarded the 2004 Nobel Prize in Chemistry. It is now known that ubiquitin-mediated destruction plays a crucial part in cell-cycle regulation, DNA repair, cell growth and immune function, as well as in hormone-mediated signalling in plants. More recently, ubiquitin has been shown to have numerous non-proteolytic functions, including involvement in vesicular trafficking pathways, regulation of histone modification and viral budding.

Given the central role of the ubiquitin system in diverse cellular processes, it is not surprising that its dysfunction contributes to cancer and to neurodegenerative and immunological disorders. An understanding of the ubiquitin system is therefore important in devising treatments for such diseases.

Aliens.

I think we’re going to need a few more examples to really make sure.